DAO Enzyme

Bloating after meals. Headaches after wine. Flushing after leftovers. Sound familiar? DAO Enzyme helps to support healthy histamine breakdown, allowing you to enjoy the foods you love with comfort and confidence.

30 Capsules

Some people have a genetic condition where they produce less diamine oxidase enzyme than what is required for normal digestion. Following certain meals, a reduced ability to process histamine can be a contributing factor to nosebleeds, eczema and other skin flare ups, loose stools, headaches, and more.

What is DAO?

Diamine Oxidase (DAO) is a naturally occurring digestive enzyme produced in the gastrointestinal tract that helps break down histamine found in food. Seeking Health's DAO supplement delivers a supplemental dose of this enzyme directly to the digestive tract. Take prior to meals to assist your body in processing dietary histamines before they are absorbed.

Seeking Health's formula features DAOgest®, a cleaner, patented, and lab-tested DAO enzyme derived from porcine kidney extract.

This Seeking Health formula was previously marketed as Histamine Digest.

Benefits of DAO Supplementation

Supports Dietary Histamine Breakdown: DAO promotes the breakdown of food-derived histamines including from aged cheeses, a variety of fermented foods, citrus, cured meats, and wine.

Promotes Digestive Comfort: DAO helps to manage occasional dietary digestive discomfort following histamine-dense meals (like excessive fullness or bloating).

Supports Healthy Histamine Metabolism: DAO works to enhances natural digestive enzyme activity in the small intestine to help maintain normal histamine balance in the gut.

Convenient Mealtime Support: DAO is easy  to take shortly before meals, offering added flexibility and confidence when dining out or enjoying complex dishes.

User Experience

As with any natural supplement, individual results will vary, but some of the benefits users have seen include:

• Expanded Diet & Freedom: Some buyers describe DAO as a "game changer" or "lifesaver" that allows them to enjoy higher-histamine foods.
• Symptom Relief: Reviewers report marked reductions in histamine-related digestive distress (bloating, cramping, heartburn), skin flushing/redness, headaches, and general gut discomfort.
• Effectiveness Compared to Competitors: Some users have noted that while cheaper DAO brands failed to work well for them, Seeking Health's formulation provided reliable and superior results.

Ingredients:

Serving Size: 1 Capsule - Servings Per Container: 30 - Amount Per Serving:

DAOgest® (porcine kidney extract) ... 4.2 mg (Diamine Oxidase Activity 30,000 HDU)

Other Ingredients: microcrystalline cellulose, vegetarian capsule (hypromellose, water, and gellan gum), and
ascorbyl palmitate.

Free of dairy, egg, fish, shellfish, tree nuts, peanuts, gluten, soy, and sesame.

Not suitable for vegetarians.

Suggested Usage:

Consult your health practitioner prior to using this or any other dietary supplement.

With meals: Take 1 DAO capsule before eating or drinking anything high in histamine (timing is critical). This is the most common use and where most people notice the most support.

On an empty stomach: This is the one most people miss and is actually quite a genius trick. Your gut bacteria and your gut's immune system also produce histamine. If you have dysbiosis, SIBO, or an overactive gut immune response, try taking 1 capsule on an empty stomach. If you feel better within 30 minutes, that tells you your microbiome or gut immune system is producing excess histamine. Continue using it this way as needed

Supporting Studies:

Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019 May 24. PMID: 31807350.

Observational study to assess the efficacy and safety of diaminooxidase (DAO) supplementation in patients with histamine intolerance (HIT). Clinical Nutrition ESPEN. DOI: 10.1016.